Epidemiologic, humanistic and economic burden of hepatocellular carcinoma in the USA: a systematic literature review
Materials & Methods
Studies describing the epidemiology and economic burden from national cohorts, any economic models, or any humanistic burden studies published 2008–2018 were systematically searched.
Results
HCC incidence was 9.5 per 100,000 person-years in most recent data, but was ∼100-times higher among patients with hepatitis/cirrhosis. Approximately a third of patients were diagnosed with advanced disease. Patients with HCC experienced poor quality of life. Direct costs were substantial and varied based on underlying demographics, disease stage and treatment received. Between 25–77% of patients did not receive surgical, locoregional or systemic treatment.
Conclusion
Better treatments are needed to extend survival and improve quality of life for patients with HCC.
Authors
A Aly, S Ronnebaum, D Patel, Y Doleh, F Benavente
Journal
Future Medicine
Therapeutic Areas
Oncology
Centers of Excellence
Strategic Market Access
Year
2020
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