Services / Modeling & Meta-Analyses

Innovative methods to assess healthcare interventions

Modeling and Meta-Analyses are powerful tools for providing payers with vital information on which to base their decisions when assessing the costs and/or benefits of healthcare interventions.

Why do we need modeling?

When payers make decisions about which technologies and/or services to fund, they must assess the clinical and economic value of feasible alternatives through consideration of costs and appropriate outcomes over an appropriate time horizon for a range of patient subgroups.

Clinical trials are designed for measurement and hypothesis testing, so they often fail to meet the requirements for decision-making.

What is meta-analysis?

Meta-analysis is a type of evidence synthesis tool used for multiple studies to improve the precision and relevance of clinical and health outcomes data. A meta-analysis evaluation will help to organise, explain, and generate a single overall answer by using all available (and appropriate) information and also identifying any important trends or patterns for future research.

The synthesized evidence can then be used to show the multiple components of a product’s value. These value components span across all four of our Centers of Excellence and can help inform nearly all of them.

A history of innovation in a range of therapy areas

Our team of experts joined OPEN Health through the merger with Pharmerit and have pioneered innovative methodologies in a range of therapy areas.

Highlights from our innovation over the years

Methods to account for treatment sequencing

Applications of Q-TWiST in immuno-oncology

Development of two-eyes ophthalmology models

Use of Bayesian statistics in comparative effectiveness

Use and expansion of mixed modeling methods in survival analysis

An unrivaled mix

We are committed to providing an unrivaled mix of technical expertise and strategic insights in the field of health-economic modeling and evidence synthesis. With our bespoke approach, we work with you to assess your needs and develop a solution that is right fitted to you.

Cost-Effectiveness Model Development

  • Economic models to support reimbursement submissions around the world
  • Early models designed to inform commercial decision-making
  • Population-based dynamic transmission models
  • Global core models and country adaptations
  • Microsimulation of individual patient disease progression, treatment pathways, and outcomes
  • Simple calculators illustrating costs and outcomes
  • User-friendly graphical user interfaces

Budget Impact Model Development

  • Nationally representative estimates of the budget impact to government payers
  • Models supporting economic value messages for AMCP dossiers
  • Graphical user interfaces and web-based applications for use in payer discussions


  • Systematic literature reviews and network meta-analyses to support economic modeling and HTA submissions
  • Clinical landscape and data comparability assessments
  • Indirect treatment comparisons of non-randomized data
  • Network meta-analysis and indirect treatment comparison of survival data
  • Meta-analysis of epidemiologic and other non-clinical data
  • Matching adjusted indirect comparisons
  • Simulated treatment comparisons

Trial Analyses

  • Survival analysis and extrapolation
  • Trial-based economic models

Digital tools to enrich value communications

Our modeling experts will guide you to apply communication and analysis tools to meet many research challenges.

Health economic models

Engaging presentation of simple or complex analysis for Excel or mobile devices

Interactive Analytics & Communications

Communication and analysis tools to meet many research challenges

Data collection tools

Simple digital platforms for data collection and immediate analysis

Why us?

Our modeling experts are actively involved in the field. We have the experience needed to partner with you in research and guide you to the right solutions.


Projects delivered


HTA submissions supported worldwide


MMA experts


Cost-effectiveness models delivered

Get in touch

To learn more about our modeling and meta-analyses research and discuss what we could do for you, please get in touch.

Maarten Treur

Modeling & Meta-Analyses Lead