Services / Modeling & Meta-Analyses

Innovative methods to assess healthcare interventions

Modeling and meta-analysis are powerful tools for providing payers with vital information on which to base their decisions when assessing the costs and/or benefits of healthcare interventions.


Why do we need modeling?

When payers make decisions about which technologies and/or services to fund, they must assess the clinical and economic value of feasible alternatives through a consideration of costs and appropriate outcomes over an appropriate time horizon for a range of patient subgroups.

Clinical trials are designed for measurement and hypothesis testing, so they often fail to meet the requirements for decision-making.

Meta-analysis

  • Systematic literature reviews and network meta-analysis to support economic modeling and HTA submissions
  • Clinical landscape and data comparability assessments
  • Indirect treatment comparisons of non-randomized data
  • Network meta-analysis and indirect treatment comparison of survival data
  • Meta-analysis of epidemiologic and other non-clinical data
  • Matching adjusted indirect comparisons
  • Simulated treatment comparisons

A history of innovation in a range of therapy areas

Our team of experts joined OPEN Health through the merger with Pharmerit and have pioneered innovative methodologies in a range of therapy areas.


Highlights from our innovation over the years



Methods to account for treatment sequencing


Applications of Q-TWiST in immuno-oncology


Development of two-eyes ophthalmology models


Use of Bayesian statistics in comparative effectiveness


Use and expansion of mixed modeling methods in survival analysis


An unrivaled mix

We are committed to providing an unrivaled mix of technical expertise and strategic insights in the field of health-economic modeling and evidence synthesis. With our bespoke approach, we work with you to assess your needs and develop a solution that is right fitted to you.


Cost-Effectiveness Model Development

  • Economic models to support reimbursement submissions around the world
  • Early models designed to inform commercial decision-making
  • Population-based dynamic transmission models
  • Global core models and country adaptations
  • Microsimulation of individual patient disease progression, treatment pathways, and outcomes
  • Simple calculators illustrating costs and outcomes
  • User-friendly graphical user interfaces

Budget Impact Model Development

  • Nationally representative estimates of the budget impact to government payers
  • Models supporting economic value messages for AMCP dossiers
  • Graphical user interfaces and web-based applications for use in payer discussions

Meta-Analyses

  • Systematic literature reviews and network meta-analyses to support economic modeling and HTA submissions
  • Clinical landscape and data comparability assessments
  • Indirect treatment comparisons of non-randomized data
  • Network meta-analysis and indirect treatment comparison of survival data
  • Meta-analysis of epidemiologic and other non-clinical data
  • Matching adjusted indirect comparisons
  • Simulated treatment comparisons

Trial Analyses

  • Survival analysis and extrapolation
  • Trial-based economic models

Digital tools to enrich value communications

Our modeling experts will guide you to apply communication and analysis tools to meet many research challenges.


Health economic models

Engaging presentation of simple or complex analysis for Excel or mobile devices

Interactive Analytics & Communications

Communication and analysis tools to meet many research challenges

Data collection tools

Simple digital platforms for data collection and immediate analysis


Why us?

Our modeling experts are actively involved in the field. We have the experience needed to partner with you in research and guide you to the right solutions.


820

Projects delivered

289

HTA submissions supported worldwide

44+

MMA experts

168+

Cost-effectiveness models delivered


Dedicated team of experts

Our team of experts, support you to generate innovative meta-analysis across a range of therapy areas.

Latest authored publications

Our researchers publish numerous peer-reviewed articles and poster presentations each year across a variety of noteworthy journals and conferences. Take a look at our latest publications or search through historical publications by journal, date, or therapeutic area.


Get in touch

To learn more about our modeling and meta-analysis research and discuss what we could do for you, please get in touch.

Maarten Treur

Modeling & Meta-Analysis Lead