Authors: J Smith, B Talon, A Martinez, K McCarrier, J Aggarwal
Published: Frontiers in Dementia, 2025
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Background
Agitation is a common neuropsychiatric symptom of Alzheimer’s dementia. Limited qualitative evidence is available to characterize the clinical meaningfulness of changes in agitation behaviors, as assessed by the Cohen-Mansfield Agitation Inventory (CMAI).
Objective
This retrospective cohort study identified adults in Optum’s Clinformatics Data Mart Database who were diagnosed with mRCC from August 2015 through July 2022 and received subsequent therapies after IO- and VEGF-based therapies. Patients were classified by the first line of treatment that they received after exposure to IO- and VEGF-based therapies. Outcomes included treatment patterns (time on treatment [ToT], time to next treatment [TTNT]), HCRU, and costs.
Materials and methods
One-on-one qualitative interviews were conducted with 15 physicians treating Alzheimer’s dementia and 15 professional caregivers. Nine patient vignettes depicting observed changes in CMAI score profiles over a 12-week study period were used as examples of different magnitudes of change in the CMAI total score.
Results
The proportion of participants affirming clinical meaningfulness varied for both physicians and caregivers within and across the nine vignettes presented; however, the four vignettes corresponding to a CMAI total score reduction of 14 or greater were considered clinically meaningful to all participants. Most physicians (8/13) and caregivers (7/13) found a total score reduction of 5 to be clinically meaningful, and some participants (2 caregivers; 0 physicians) articulated that even minimal changes could be clinically meaningful depending on the type of behavior.
Conclusion
Participants who regularly treat people with Alzheimer’s dementia described a significant burden associated with agitation behaviors and provided qualitative examples highlighting that even minor reductions in the frequency of such behaviors can have meaningful benefits for the patient’s care and the burden on professional caregivers and family members.
